Both are GHRH analogs that stimulate your pituitary to release growth hormone naturally. Sermorelin is a broad-spectrum GH secretagogue great for overall anti-aging benefits, while Tesamorelin is specifically studied for visceral fat reduction and body composition improvement.

Most patients notice improved sleep and energy within the first 2–4 weeks. Noticeable changes in body composition, lean muscle, and fat reduction typically appear within 3-6 months of consistent use. Results build gradually as your body's natural HGH levels are restored.

No, and that's an important distinction. Synthetic HGH replaces your body's natural production, which can suppress your pituitary over time and carries a higher risk profile. Sermorelin and Tesamorelin stimulate your own pituitary to produce HGH naturally, preserving your body's feedback loops.

Side effects are generally mild and may include transient injection site reactions, mild water retention, or headaches in the first few weeks as your body adjusts. Most patients tolerate the therapy well. Your prescribing clinician will monitor your progress and adjust dosing as needed.

Plans start at $199. Your treatment plan is personalized based on your labs and health goals. Most HSA and FSA accounts are eligible, making this accessible without out-of-pocket strain.

Complete a short online health intake, no in-person visit required. A licensed clinician will review your information, and if appropriate, send your prescription directly to a compounding pharmacy. Your treatment arrives discreetly at your door within 1–2 business days.

Direct Meds operates with multiple layers of oversight. All prescribing physicians are licensed in your state and vetted for peptide therapy. Our compounding pharmacies are US-based 503A facilities. Our medical director, a practicing physician, has reviewed our entire provider and pharmacy network. We also maintain LegitScript certification, the telehealth industry's most recognized compliance authority, which independently verifies our pharmacies, doctors, and software providers.

Direct Meds currently serves all US states except Alabama, where telehealth prescribing of certain medications is restricted under state law.

There are no contracts. Our plans are month to month and you can cancel anytime by emailing [email protected] or calling (888) 696-7176. We stand behind our results, so if you're not satisfied, let us know and we'll make it right.

Your medication is dispensed by US-based 503A compounding pharmacies that prepare each prescription individually in response to your doctor's order. They follow USP 795 and USP 797 standards and are licensed by state pharmacy boards. Compounded peptides are not FDA-approved as finished drugs, but are prepared under applicable federal and state compounding laws by licensed professionals.

Sermorelin and Tesamorelin are administered as a small subcutaneous injection, typically in the evening before bed since growth hormone is naturally released during sleep. The needles are insulin-sized and most patients find the process quick and painless. Your clinician will walk you through the full protocol at your initial visit and our support team is always available if you have questions.

Prescriptions received before 2 pm CT ship the same day via next-day UPS in a temperature-controlled package. Weekend orders (Friday through Sunday) ship the following Monday. You'll receive a tracking number for every shipment and all orders are fully insured. If you have any delivery issues, contact our support team at [email protected] or (888) 696-7176.

Our support team is available by email at [email protected] or by phone at (888) 696-7176. You can also visit our Patient Services page to submit a message, request a refill, or check order status. We're here whenever you need us.